Modafinil is a eugeroic medication that enhances brain function. This drug is becoming popular among college students and entrepreneurs to combat fatigue, increase productivity and intellectual performance. Modafinil is now considered one of the most reliable cognitive enhancers on the market.

Modafinil is used clinically to treat conditions like sleep disorders like, assist people who suffer from sleep apnea and for people with shift work disorder who suffer from excessive sleepiness due to having a work schedule.

However, it’s essential to consider Modafinil interactions with various substances.  In this post, we’ll discuss the effects of combining modafinil so that you can safely get the most out of your modafinil use.


Modafinil with Food

Modafinil is not dangerous when combined with any foods. It can be taken with food or without food. Though taking modafinil with food may delay your body’s absorption of the drug, but that doesn’t mean the drug is no longer bioavailable, only that it will take longer to be absorbed. According to research, if you coadministered Modafinil with food, the drug absorption is delayed about one hour. You also need to take Modafinil with your morning meal. Taking Modafinil with evening meal may lead to trouble in sleeping at night.


Modafinil With Caffeine

dried coffee beans

Caffeine is among the most consumed psychoactive substance in the world. However, it worth asking if Modafinil with Caffeine is safe and how do the two drugs interact, given that so many people drink coffee. The combination of Modafinil and Caffeine does not cause a severe side effect, but Modafinil can increase the impact of Caffeine when used together. Therefore, please exercise caution when taking both. Try drinking only one cup of coffee with modafinil if you drink 3 cups a day before.


Modafinil and Coffee

Taking modafinil with coffee provides the optimal level of mental stimulation. Like Modafinil, coffee alters the brain chemicals responsible for sleep and for being awake, which means you have to be very careful when using the two of them together. Both coffee and Modafinil work on the central nervous system, which means the effects will be concentrated when used together.  Coffee plus modafinil could impair performance if you’re an anxious person by nature; therefore you need to be very careful when using the two of them together.


Modafinil and Alcohol

Although there is no outright contraindication on mixing Modafinil with alcohol, yet it’s a bad idea. The reason is that you will underestimate how intoxicated you are. Modafinil combats alcohol’s depressant effects. The result is that you will continue to drink more because you do not feel drunk. Also, Modafinil and alcohol have the potential to dehydrate you, so combining both increases the risk of dehydration. Be mindful of the fact that it takes more than 12 hours for Modafinil to pass out of your system if you are planning to drink alcohol later in the day.


Modafinil with Drugs

spilled bottle of medicine

Modafinil drug interactions can be difficult to comment on due to the genetic differences difference between the users. Modafinil is an inducer of three hepatic enzymes: CYP1A2, CYP3A4, and CYP2B6, which means it will increase the expression of these enzymes and in turn decrease the effectiveness of drugs. The general guide is that you should make sure that your pharmacist and your physician know about all of the drugs you are taking before you start taking Modafinil. You also need to inform them about your vitamin and herbal supplements. Keep in mind that just because two drugs interact doesn’t mean that you have to stop taking one of them. Your physician should tell you how to manage them without causing any of the unwanted side effects.


Modafinil with Adderall

Adderall is a potent dopamine-releasing agent prescribed for the treatment of ADHD. Adderall, help someone diagnosed with ADHD to be more focused, attentive and to control their behavior. Adderall contains a combination of d-amphetamine and l-amphetamine in a 3:1 ratio. It’s suggested that you should only take one stimulant at a time. A study reveals what happens when modafinil is combined with methylphenidate and d-amphetamine. Here’s what they discovered: volunteers exhibited delayed uptake of modafinil by about one hour after taking 200mg of modafinil with 10mg d-amphetamine. Some doctors may prescribe a combination of Adderall and modafinil for some people with ADHD, but this is something that should only be left up to a doctor.


Modafinil and Weed (Marijuana)

dried lump of marijuana leaves

Taking modafinil with weed increases the effect of cannabis while decreasing fatigue. The cloudiness/sluggishness/fogginess often associated with marijuana will disappear. Your mind will be fully active and alert, but your body may feel a little slow. It’s considered an improvement on the intoxicating effects of marijuana alone. Taking marijuana with modafinil also makes it easier to fall asleep.



Modafinil with Piracetam

Piracetam is a modulator of AMPA-type glutamate receptor while Modafinil decreases GABA and increases the neurotransmitter glutamate. Modafinil and piracetam activate glutamate receptors to boost excitatory signaling, so you need to be aware of the theoretical risk of excitotoxicity when combining both. It’s best to take both substances slow and take lower doses. Try taking 100mg of modafinil with 1g of piracetam if you usually take modafinil of 200mg and 2g of piracetam before.


Modafinil and Ritalin

Ritalin is a CNS stimulant that affects the brain chemicals involved in hyperactivity. The interaction between Ritalin and modafinil is that both are cerebral stimulants. According to research, combining both do not show any adverse reactions. For instance: co-administering of methylphenidate (Ritalin) does not impact modafinil’s half-life, maximum concentration (Cmax), the volume of distribution, total clearance, and area under the concentration-time curve. While there may be a few situations where using Ritalin with Modafinil is justifiable, it is not a good idea in most cases.


Modafinil and Xanax

Xanax is a great drug if you have an anxiety disorder. According to Dr. Carlo Carandang, a professional psychiatrist, modafinil plus Xanax can be a useful combination for the treatment of social anxiety. Xanax enhances the effect of GABA and Modafinil is a mild dopamine-reuptake inhibitor. Both of these effects on GABA and dopamine will decrease stress and make it easier to relate to others.


Modafinil and Noopept

Noopept is a Russian-developed synthetic drug that is a peptide analog of Piracetam. Noopept and Modafinil are prevalent among individuals interested in cognitive enhancement and boosting their productivity. Noopept works on learning ability, memory, and focus, while Modafinil promotes intense energy, motivational drive, alertness, and wakefulness. Stacking Modafinil with other nootropics such as Noopept improves your memory, and enhanced productivity, creativity, and concentration.


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